C-Clown’s final EP, “Let’s Love”, was released in 2014, as unfortunately the group officially disbanded on 5 October 2015, three years after its creation, and the members pursued their individual interests. Later in 2012, C-Clown released its second EP, “Young Love”, which performed better than the first EP, and the following year the band released its third EP, “Shaking Heart” (2013), which reached the top of the Korean charts. The project debuted at Number 92 on the Korean charts, and the band made its debut performance on Mnet’s TV program “M Countdown” the following day. C-Clown released its first EP (mini-album) “Not Alone” on 18 July 2012 with six members, namely Rome (Christian), SiWoo, Kang Jun, T.K, Maru, and Ray. Shortly afterwards, he joined the K-pop boy band Crown Clown (popularly known as C-Clown) under Yedang Entertainment, using the stage name Rome, as the lead singer and rapper of the group. After two episodes on the show, he left to pursue a career in music. He participated in the second season of “Let’s Go! Dream Team”, a Korean TV show that featured newbies in the entertainment industry. At the age of 18, Christian relocated from Sydney back to Seoul, South Korea, where he became a B-boy.Ĭareer C-Clown Boy Band: Yedang EntertainmentĬhristian Yu built his career in South Korea because of how things were fast-paced there, especially with the growing popularity of Korean popular – K-pop – at the time. Upon matriculating, Christian enrolled at the University of Sydney, however, he didn’t graduate, as he dropped out to pursue his dreams of becoming a renowned musician. In Christian’s last year of high school, he was diagnosed with bipolar disorder which, according to him, explained his extreme mood swings. Christian attended a Performing Arts School, and joined a heavy metal band in middle school, in which he was the lead drummer. His love for music also attracted him to dancing. He used to frequent circuses, where there would always be musicals on the play. His love for music was inspired by “Cats”, the first musical he ever watched. Further studies should verify its effect on OS.A post shared by Christian Yu parents separated when he was young, so he was raised mainly by his mother. Lenalidomide maintenance can prolong PFS in CLL. Lenalidomide maintenance was associated with a statistically significant effect in prolonging PFS (HR, 0.43 95% CI, 0.28–0.68 I 2 = 57%) and higher proportion of SAE (OR 4.64 95% CI 2.96–7.26 I 2 = 0%) and exhibited no difference in OS (HR, 0.62 95% CI, 0.29–1.30 I 2 = 52%) observation/placebo. Four articles (733 patients) met the selection criteria. Hazard (HR) and odds ratios (ORs) with 95% confidence intervals (CIs) were calculated. Secondary outcomes were Grade 3–4 neutropenia, treatment discontinuation (TD), serious adverse events (SAE), and fatal adverse events (FAE). Trial sequential analysis examined analytical power in primary outcomes. Primary outcomes were progression-free survival (PFS) and overall survival (OS). Randomized controlled trials published before March 2022 were retrieved from databases. However, the efficacy and safety of lenalidomide maintenance are still debated. Maintenance therapies aim to achieve deep remission. Despite durable responses and sustained remission rates to frontline therapy, CLL is still incurable within standard therapy and eventually relapses. Chronic lymphocytic leukemia (CLL) is the most common lymphoproliferative disease in adults.
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